THE MEDICAL PICKWICK is the title of a new journal for medical readers, yet not a medical journal, the first number of which bears date, January, 1915. The magazine is published at Saranac Lake, N. Y., and Dr. Walter M. Brickner is the editor, which fact is a guarantee that the journal will not be lacking in humor. But the aim of the publication is not alone to be humorous, it is to be entertaining as well, to treat of all matters, except scientific, relating to medicine. The January issue is a "dandy," and with such names as Billroth, Coe, Chambers, Garrison, Morris, Ransohoff and others affixed to its sipcy menu, its enjoyable and interesting character is assured. It is a journal large quarto in size, beautifully printed on splendid paper, illustrated, teeming with fun, frolic and philosophy, run by doctors for doctors and their friends, in which to place in imperishable "printer's ink" evidences of literary tenchnique, poetry and satire emanating from medical men. Subscription price, $2.00 per annum, and well worth it.

WINTER COUGHS AND COLDSS-The severe and often intractable coughs of winter colds too often owe their continuance to systematic weakness. To relieve and overcome them it is essential to raise the vitality and nutrition of the whole body. For this purpose there is no remedy so prompt and reliable in its effects as Gray's Glycerine Tonic Comp. and its easily proven efficiency in affections of the respiratory tract chronic bronchitis, incipient tuberculosis, asthma, laryngitis and catarrhal disease in general-readily accounts for its widespread use by the profession in this class of ailments.

Its regular systematic administration rapidly restores the nutritional balance and as patients gain in strength and weight usually the most intractable coughs grow less and less and finally disappear.

THERAPEUTIC NIHILISM:-In a very practical paper presented to the Medical Society of Virginia, appearing in the Charlotte Med. Jour., January, 1915, Dr. S. W. Dickson, of Marion, Va., very logically suggests the enormous redundancy and overwhelming multiplicity of the articles in our Materia Medica, and the varying strength of many of the more important remedies prepared by different manufacturing pharmacists, as the important factors in this present day heresy. He concludes his paper with the following ters paragraph:

"With fewer drugs and with more exact knowledge of drug action, knowing what to expect from drugs, and with drugs coming up to a required and expected standard, the results obtained should remove the doubts we all have and cure us of therapeutic nihilism by oftener curing our patients."

ADDITIONAL SUCCESS OF LISTERINE:-In the United States District Court, Southern District of New York, the Lambert Pharmacal Co. secured a decision restraining the Bolton Chemical Corporation from using the name “Listogen,” January 11, 1915. The District Judge, Hon. Learned Hand, stating among other points that the name was too much like that of the well known preparation, which from its real merits had become standard. He farther stated that it was calculated to induce substitution of an unknown for a well-known and established product of which, the records showing said the Judge, "that the sales for now many years have been of many millions of bottles, and that it has become an article of very common use in many countries."

MELLIN'S FOOD was the first preparation of maltose and dextrin presented to physicians in serviceable form, and it stands today as a true representation of Liebig's principles which are now so generally applied to scientific infant feeding.

There is a distinct advantage to the physician in the employment of Mellin's Food where a maltose and dextrin product is desired, and we cannot emphasize too strongly the importance of using a product scientifically prepared from carefully selected material and by clean methods if successful results are to be obtained. It is well balanced, easily assimilated and highly nourishing.

THE BOWEIS ARE SECRETORY ORGANS:-It is the failure of the secretory function of the bowel, together with a poor bile secretion, which, in nine cases out of ten, is responsible for constipation.

Most cathartics altogether overlook this factor and address themselves solely to a stimulation of the musculature. Some even inhibit intestinal secretion. The result is a rapid, unsatisfactory bowel movement, followed by paralytic reaction.

Pil. Cascara Comp. Robins is a rational therapeutic formula, which promotes a natural flow of secretions, which is, in turn, the physiologic stimulant of peristalsis. Thus a normal evacuation is produced, without subsequent inhibition.

CITY VIEW SANITARIUM:-Dr. John W. Stevens, physician in charge of this excellent institution, located in the immediate vicinity of Nashville, announces the opening January 1, 1915, of the new rifty room department. With two new buildings, one for each sex, they are prepared to offer accommodations for patients, male and female, far superior to those afforded in the past, and have an institution thoroughly modern and fully equipped in every respect.

THE NUTRITION OF PULMONARY TISSUES:-During the winter and spring months the management of diseases of the bronchi and lungs is one of the most important functions of the physician. The treatment of acute infections must, of course, be largely symptomatic, but it is generally recognized that the best chance of securing results in chronic diseases of the bronchi and lungs is afforded by an agent that supplies nourishment to these tissues, and for such a purpose Cord. Ext. Ol. Morrhuae Comp. (Hagee) will give the utmost satisfaction. It contains the essential qualities of cod liver oil, but is free from its nauseous properties, for which reason it should be selected whenever cod liver oil is indicated.

NERVOUSNESS AND SLEEPLESSNESS:-Business men frequently consult physicians for relief from nervousness which may even prevent rest at night. Usually there are business worries on the minds of such patients. In those cases the physician often times is hard put to choose an agent that will give relief and yet produce no bad effects. However, if he chooses Pasadyne (Daniel) his patient will secure relief from the nervousness, and also refreshing sleep, and without untoward effect, too. Pasadyne (Daniel) is a concentrated tincture of passiflora incarnata. This distinctive name is given it to protect the physician and patient from the substitution of an inferior product.

A sample bottle may be had by addressing the laboratory of John B. Daniel, 34 Wall Street, Atlanta, Ga.

PROFESSIONAL EXPERIENCE and comparative study have proved that there is a "difference," in results, between Antiphlogistine, and its closest imitator. Therefore, physicians should write "Antiphlogistine" to avoid "substitutes." "There's only one Antiphlogistine."

"EGGS IS EGGS":-If you are interested in "hen fruit," and every doctor should be these days, write to Dr. W. O. Sullivan, "R. F. D.," Newbern, Tenn., and negotiate for some of his fine S. C. Buff Orpingtons.

IODINIZED EMULSION (Scott) is an ideal intestinal antiseptic, and is indicated in typhoid and other wasting diseases, dysentery, chronic diarrhea and gastro-intestinal troubles.

THE PRIVATE MATERNITY HOME, located at 4496 LaClede Avenue, St. Louis, Mo., established in 1886, is strictly ethical and well worthy of your consideration. Correspondence promptly attended to.

Selections

ETIOLOGY AND TREATMENT OF PELLAGRA:-For two and a half years I have made a careful study of intestinal bacteria associated with pellagara, but the intestinal flora and fauna include so many species I have looked with doubt on the pathogenicity of any of them until it is definitely proven. In addition to the colon group of bacteria which are found in feces of pellagrins, I have observed with much interest a bacillus which must be the cause of the disease.

This bacillus is from four to ten microns in length and is more sharpened at the ends than others of the colon group. It develops by spore formation and presents itself in many forms. When spore formation is about to occur a point of cloudiness or an area of bright refraction appears in the protoplasm and the cell generally elongates. The spore enlarges, the cell membrane bursts and the young bacillus emerges through the opening. On first appearance the young bacillus is very active and for a few seconds it is spiral or cork-screw shaped. It gradually elongates and becomes less and less motile. Later it may appear rod-shaped, slightly curved or as a long undulating thread, often suggesting the appearance of a streptococcus before sporulation occurs.

In all its forms the bacillus is motile. The different sized cells as well as the bacillus itself have the power of independent motion, and so varied is the appearance of the organism, the microscopist often believes he is dealing with many varieties. It is best studied in a fresh stool, in a warm room, but it is motile in a specimen two weeks old or as long as there is moisture. Morphologic changes, however, are seldom observed except in fresh specimens. The bacillus is aerobic; anaerobic, and is discolored by Gram's and Gabbet's methods of staining. The spores are little affected by these stains.

Daily specimens from a single case of pellagra vary much in appearance. One specimen may show an abundance of spores and very few if any baccilli, while another specimen may reveal a dozen or more bacilli in one field with very few cells. A thin stool placed in an incubator often changes its appearance in forty-eight hours. So numerous are these bacteria in many specimens, they compose five per cent of the solid portion of the excrement and more than seventy-five per cent of all the motile organisms present. Sterile feces afford the best culture medium. They grow well in this medium at a temperature of eighty (80) to ninety (90) degrees.

Animal inoculation experiments have not been very successful. A mild diarrhoea and nervousness was produced by feeding a cat on food contaminated with pure cultures and the bacilli were again observed on microscopic examination. In a man pellagra has been induced by accidental transference of cultures of the bacilli. Pharyngitis and bronchitis developed within three days and was soon followed by definite intestinal and nervous symptoms of pellagra. The pharyngitis and bronchitis subsided in about ten days, but the other symptoms remained until successful treatment was administered. The microscope revealed the organism in its many forms for four weeks.

Of the sixty-four cases of pellagra examined, the bacilli were seen in great numbers. Twenty-one of these have been examined many times and the organism was present in every instance for many months. The organism has not been seen on examination of healthy individuals and those suffering from other diseases.

The bacillus in culture has been tested by many drugs. A one per cent solution of ichthyol seemed to have a most decided effect. I have partially tested this drug on twentytwo cases of pellagra within the last ten weeks. One or two five grain enteric coated pills three or four times a day for three weeks seems to cure the average case. Nearly