THE TUBERCULOUS INVALID:-The pricking of the Friedmann bubble but served to still further confirm and accentuate the vital importance of the well defined methods of treatment for tuberculosis that have given such encouraging results, i. e., fresh air, sunshine, rest, nutritive reinforcement and judicious medication. A proper combination of these four remedial factors is practically certain to place the incipient tuberculous invalid upon the road to recovery, if the patient is intelligently handled and the treatment persisted in. While it is, of course, acknowledged that the first three non-medicinal agents referred to constitute the vital elements of the upbuilding régime, considerable aid is afforded by judicious medication. Hematinic reinforcement should certainly not be neglected, in view of the secondary anemia which is almost always apparent. Among the agents which have produced the best results in the revitalization of the blood, Pepto-Mangan (Gude) is the most generally eligible and acceptable. As it is thoroughly palatable, neutral in reaction, free from irritant properties and devoid of constipating effect, the digestion of the patient is not disturbed, while the appetite and general vital tone improve more rapidly and satisfactorily than when hygienic and nutritive measures are depended upon exclusively.

ANADEMIN is a common remedy for the common symptom-Dropsy, and is a scientific compound of the active principles of the freshest drugs, selected with great care to produce a remedy of uniform strength. It is advertised to the profession only. A liberal sample for trial treatment will be mailed to any physician on application to the manufacturers. It acts upon the circulation, accelerates the flow in the thoracic duct, rapidly returning the serum to the blood by the lymphatic channels as well as by resorption into the blood by healthy arterial tone, from whence it is removed by diuresis and purgation.

There is no other preparation, combination or therapeutic agent of its class, combining the active principles of Apocinum, Strophanthus, Squill and Sambucus, giving the same results as Anedemin. Physicians are cautioned against imitators, substitutes or inferior combinations.

For sample and literature write to Anademin Chemical Co., Chattanooga, Tenn.

IN ANEMIA AND CHLOROSIS, where the motor functions of the stomach are not disturbed, yet there is a decrease in secretion of gastric juices, Seng is of greatest value as collateral treatment.

GLYCO-THYMOLINE IN TYPHOID FEVER:-To keep the alimentary tract as free as possible from fermentable matter, to inhibit as far as possible the activity of the putrefactive bacteria which normally inhabit the intestinal canal, and to eliminate the toxin produced by the Bacillus Typhosus as rapidly as possible are desirable results to accomplish in treating Typhoid cases.

The power of Glyco-Thymoline to produce these results is amply proven by clinical reports from eminent physicians in all parts of the country.

The distressing condition of fissured tongue and "cracked" lips is immediately relieved and the sordes of teeth and mouth quickly removed by the use of Glyco-Thymoline."

DANGER DUE TO SUBSTITUTION:-Hardly another of all the preparations in existence offers a wider scope to imposition under the plea of "just as good" than the scientifically standardized Eucalyptol. The more recent fraud practiced in regard to this product is an attempt to profit by the renown of the firm of Sander & Sons. In order to foist upon the unwary a crude oil, that had proven injurious upon application, the firm name of Sander & Sons is illicitly appropriated, the make-up of their goods imitated, and finally the medical reports commenting on the merits of their excellent preparation are made use of to give the desired lustre to the intended deceit. This fraud, which was exposed at an action tried before the Supreme Court of Victoria, at Melbourne, and others reported before in the medical literature, show that every physician should see that his patient gets exactly what he prescribes. No "Just as Good" allowed.

THE DIETETIC AND HYGIENE GAZETTE, which is just completing the thirtieth year of its existence, has been purchased by the Critic and Guide Company, and, beginning with January, 1915, will be consolidated with the Critic and Guide, and the combined journals will be under the editorship of Dr. William J. Robinson. The offices of publication are at 12 Mt. Morris Park W., New York City.

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TACHYCARDIA:— -When functional," as in "tobacco heart," this disease is often difficult to treat. As in other forms of cardiac neuroses, the use of the disturbing stimulant must be interdicted. If the heart is sustained in the interim between the paroxysmal attacks by Cactina Pillets the organ will be strengthened and the attacks decreased.

MISTAKEN PROPHETS:—Sixty-seven years ago the prophets were quite as confident as they are today, but they had not reduced the business to such a science, and it lacked much of being exact. For instance, a newpaper published in 1847 contained an article, copied from the Encyclopdia Britannica, by a statistical expert, in which he estimated that the population of the United States in 1905 would be about 168,000,000 people. In 1966 we are to have 672,000,000. In 2002 we are to have a population of 1,344,000,000, and by 2030 we are to have a population of 2,688,000,000. If the guess at the population in 1905 is to be taken as a criterion we need not be afraid of being elbowed into the sea in the near future.

NERVOUS IRRITABILITY FOLLOWING A DEBAUCH:-For the relief of the nervous irritability following over indulgence in alcohol,PASADYNE (Daniel) will produce results of a highly gratifying character. These patients want cessation of the intense irritability, they want sleep, and in PASADYNE (Daniel) they may secure them. PASADYNE (Daniel) the concentrated tincture of passiflora incarnata is the ideal sedative. Effective and free from untoward results, it can be given without a feeling that evil effects may follow.

A sample bottle may be had by addressing the laboratory of John B. Daniel, 34 Wall Street, Atlanta, Georgia.

A GENERAL CARDIAC TONIC:-Cactina Pillets are extremely useful as a general cardiac tonic, and are preferable for prolonged treatment. They should be included in the treatment of endocarditis, pericarditis, myocarditis and angina; in neurasthenia of old age, and when given during gestation will strengthen the heart of both mother and child.

The physician who desires to use the best preparation of Cereus Grandiflorus should specify Cactina Pillets.

RUSSIA PROMISES TO ADD TEN MILLION more men to those already in the field, which, it is estimated, will amount to about fifteen million all told. According to German authorities, the Czar has lost one million six hundred thousand soldiers, but if ten million more can be put in their places, the loss will not be felt. Fifteen million ought to be able to kill the soldiers of an ordinary nation with sticks.

Selections

GAS GANGRENE:-Attempts are being made at the Lister Institute to provide a suitable antitoxin for use in "gas gangrene," the condition which has proved to be the great surgical novelty of the war. As a result of an investigation just finished by Sir Anthony A. Bowlby, C. M. G., Colonel, A. M. S., Consulting Surgeon to the Forces Overseas, and Dr. J. Sidney Rowlands, it is believed that the disease is associated with the bacillus of malignant edema. A sample of earth from a trench was used in solution and with a few drops of this a guinea-pig was inoculated. The animal died within eighteen hours. Post-mortem examination showed the presence of a similar gangrenous cellulitis, and that the animal was infected with a spore-bearing anerobic organism belonging to the same group as the specific organism of malignant edema. The conclusion has therefore been drawn that the gangrene found among the wounded is a "traumatic infection" beginning at the moment of injury, due to infection from the soil, and quite distinct from so-called "hospital gangrene."

Cases seen by these observers were limited to wounds of the extremities, especially where large bones were shattered and muscles extensively torn and extruded. Fractures of the femur were especially common, but cases were not necessarily limited to fractures. The onset was as early as thirty-six hours, and death resulted as early as the third day. Swelling of the injured part was seen at the beginning, followed by severe pain, due probably to tension. In the latter stage complete numbing manifested itself. The discharge from the ragged and sloughy wound was characteristically offensive. The skin assumed a dark purplish or slate-colored hue, if not previously discolored by extravasated blood, and later the color approached green. As the condition advanced it became nearly black, and finally the slough appeared black and leathery. Beyond the dis

colored area "the limb was swollen with gas and fluid exudation, and an emphysematous crackling could be elicited on pressure with the hand. This may spread to a distance of as much as a foot above the actually gangrenous area, and so rapid is the extension of the gangrene that the whole of the lower extremity may be completely mortified by the third day." High temperature was rare, 99-100 degrees being the average. Respiration was sometimes hardly perceptible, although it was only slightly quickened. The heart's action was feeble. Death appeared to be due to cardiac failure. In the severest cases the odor from the limb was so overpowering that a thorough post-mortem was almost impossible. Incisions before or after death caused gas and sanious fluid to bubble out. Pus was only slight.-London Letter, in Cin. Lancet Clinic, Dec. 19, 1914.

METHYLENE BLUE SILVER IN BUBOES:-Saphier and von Zumbusch (Deut. med. Woch.) report their experiences with methylene blue silver in 124 cases of suppurative inguinal adenitis. The results were as follows: 10 per cent of the cases were cured in two days; that is, at the first change of dressing the point of puncture was closed, no signs of inflammation persisted and no pus or serum could be obtained either by suction or pressure. In twenty per cent it took three to five days, in thirty per cent six to eight days and in thirty-five per cent about two weeks to eradicate the buboes. In 5 per cent of the cases the virulent type of bubo developed, the prognosis in these cases having been bad from the outset, but even here a more beneficial effect was noted than in patients treated with the usual methods. The time required to terminate the process was not in accordance with the size of the inguinal swelling. Very small buboes occasionally were virulent, while very large ones, at times already discharging pus, frequently healed with astonishing rapidity. The following technique was employed: The diseased area was shaved, cleansed